PGT-S (Preimplantation Genetic Testing for Structural Rearrangements)
Discover Humgene’s PGT-S Service: Your Solution to Healthy Embryos and Successful Pregnancies
Introduction to PGT-S at Humgene
At Humgene, we understand that every journey to parenthood is unique, and sometimes it involves navigating complex genetic challenges. One such challenge can be chromosomal structural abnormalities, which can significantly impact fertility and pregnancy outcomes. That’s where our Preimplantation Genetic Testing for Structural Rearrangements (PGT-S) comes into play.
PGT-S is a specialized service offered at Humgene to screen embryos for chromosomal structural rearrangements before implantation. This advanced testing method helps to ensure that only embryos with the correct chromosomal structure are selected for transfer, thereby increasing the chances of a successful pregnancy and reducing the risk of miscarriage or genetic disorders.
If you’re a couple dealing with recurrent pregnancy loss, previous failed IVF cycles, or known chromosomal abnormalities, PGT-S could be the solution you’ve been searching for. Let’s dive into how this cutting-edge service can make a difference in your fertility journey.
Understanding PGT-S: What It Is and How It Works
What is PGT-S?
PGT-S (Preimplantation Genetic Testing for Structural Rearrangements) is a procedure used in conjunction with In Vitro Fertilization (IVF) to identify embryos that carry chromosomal structural abnormalities. These abnormalities, such as translocations, inversions, or deletions, can lead to implantation failure, miscarriages, or the birth of a child with genetic disorders.
By analyzing the genetic material of embryos created through IVF, PGT-S helps in selecting embryos with a normal chromosomal structure, significantly increasing the chances of a successful pregnancy and a healthy baby.
How Does PGT-S Work?
- IVF Cycle Initiation: The process starts with an IVF cycle, where eggs are retrieved from the ovaries and fertilized with sperm in a laboratory to create embryos.
- Embryo Development: These embryos are cultured until they reach the blastocyst stage (around 5-6 days after fertilization).
- Embryo Biopsy: At this stage, a few cells are carefully removed from each embryo for genetic analysis. This procedure, known as an embryo biopsy, is performed with precision to avoid harming the embryo.
- Genetic Testing: The biopsied cells undergo comprehensive genetic analysis to detect any chromosomal structural abnormalities. Our advanced techniques allow for the identification of rearrangements such as translocations, inversions, duplications, or deletions.
- Embryo Selection: Based on the results of the genetic testing, embryos with the correct chromosomal structure are selected for transfer. These embryos have a higher likelihood of successful implantation and development into a healthy baby.
Why Choose PGT-S at Humgene?
Choosing PGT-S at Humgene comes with several benefits tailored to improve your chances of having a healthy pregnancy and baby. Here’s why our PGT-S service stands out:
- Comprehensive Screening for Structural Rearrangements
PGT-S provides a thorough examination of embryos for structural chromosomal abnormalities that standard genetic testing might miss. This detailed screening ensures that only embryos with a normal chromosomal structure are considered for transfer, reducing the risk of complications and increasing the likelihood of a successful pregnancy.
- Improved Pregnancy Outcomes
By identifying and selecting embryos without structural rearrangements, PGT-S significantly enhances the chances of successful implantation and ongoing pregnancy. This is particularly beneficial for couples who have experienced recurrent miscarriages or failed IVF cycles due to chromosomal issues.
- Tailored to Your Unique Genetic Profile
At Humgene, we understand that every couple’s genetic makeup is different. Our PGT-S service is customized to meet your specific needs, taking into account your genetic history and any known chromosomal abnormalities. This personalized approach ensures that your fertility treatment is aligned with your unique genetic profile and reproductive goals.
- State-of-the-Art Technology
We use the latest advancements in genetic testing technology to perform PGT-S. Our cutting-edge laboratory techniques allow for highly accurate detection of chromosomal rearrangements, providing you with the most reliable results and the best chance for a healthy pregnancy.
- Expert Guidance and Support
Our team of experienced genetic counselors and fertility specialists at Humgene is dedicated to supporting you throughout your PGT-S journey. From initial consultation to post-treatment care, we are here to provide you with expert guidance and compassionate support every step of the way.
- Peace of Mind
PGT-S offers reassurance and confidence in your fertility treatment. Knowing that your embryos have been thoroughly screened for chromosomal abnormalities gives you peace of mind and reduces the anxiety associated with potential genetic issues.
Who Should Consider PGT-S?
PGT-S is particularly beneficial for couples facing specific genetic and reproductive challenges. Here are some scenarios where PGT-S can make a significant difference:
Couples with a History of Chromosomal Rearrangements
If you or your partner have a known chromosomal rearrangement, such as a balanced translocation, PGT-S can help ensure that these abnormalities are not passed on to your children. This reduces the risk of miscarriage and genetic disorders associated with unbalanced chromosomal arrangements.
Recurrent Pregnancy Loss
Couples who have experienced multiple miscarriages often find PGT-S valuable. Chromosomal structural abnormalities are a common cause of recurrent pregnancy loss, and PGT-S helps identify embryos without these issues, increasing the likelihood of a successful pregnancy.
Previous IVF Failures
If you have had unsuccessful IVF cycles, PGT-S may be the key to understanding why. By screening embryos for chromosomal rearrangements, PGT-S can identify healthy embryos that are more likely to implant and develop successfully, improving your chances of a positive outcome.
Advanced Maternal Age
Women of advanced maternal age are at a higher risk of producing embryos with chromosomal abnormalities. PGT-S can help detect these issues early, allowing for the selection of embryos with a normal chromosomal structure and increasing the chances of a healthy pregnancy.
How PGT-S is Performed at Humgene
At Humgene, we follow a meticulous and personalized approach to performing PGT-S, ensuring the highest standards of care and accuracy. Here’s a step-by-step guide to what you can expect from our PGT-S service:
Step 1: Initial Consultation
Your journey with PGT-S begins with an initial consultation with one of our genetic counselors and fertility specialists. During this session, we’ll review your medical and genetic history, discuss any known chromosomal abnormalities, and explain the PGT-S process in detail. This helps us tailor the PGT-S procedure to your specific needs and circumstances.
Step 2: IVF Cycle and Embryo Creation
PGT-S is performed as part of an IVF cycle. We’ll guide you through the process of ovarian stimulation, egg retrieval, and fertilization to create embryos. These embryos will be cultured in our advanced laboratory until they reach the blastocyst stage.
Step 3: Embryo Biopsy
At the blastocyst stage, our experienced embryologists will carefully biopsy a few cells from each embryo. This process is done with precision to ensure the integrity and viability of the embryos. The biopsied cells are then sent to our genetic laboratory for analysis.
Step 4: Genetic Analysis
The biopsied cells undergo comprehensive genetic analysis to detect any chromosomal structural abnormalities. Our state-of-the-art technology allows us to identify specific rearrangements such as translocations, inversions, duplications, or deletions with high accuracy.
Step 5: Embryo Selection and Transfer
Based on the results of the genetic analysis, we’ll select the healthiest embryos with the correct chromosomal structure for transfer. You’ll receive a detailed report on each embryo’s genetic status, helping you make informed decisions about your treatment. The selected embryos are then transferred into your uterus to achieve pregnancy.
Step 6: Ongoing Support
After the embryo transfer, we provide continued support and monitoring throughout your pregnancy journey. Our team is here to ensure your comfort and answer any questions you may have along the way.
Real-Life Success Stories
Adanna and Kelechi’s Journey with Balanced Translocation
Adanna and Kelechi were devastated after multiple miscarriages due to Kelechi’s balanced translocation, a chromosomal abnormality that often led to unbalanced embryos. They turned to Humgene’s PGT-S service for help. Through our advanced genetic testing, they were able to select embryos without the translocation issue. Today, Adanna is happily expecting a baby boy, and the couple feels deeply grateful for Humgene’s expertise and support.
Yemi and Funmi’s Hope After Recurrent IVF Failures
Yemi and Funmi had gone through several unsuccessful IVF cycles, each time feeling more disheartened. Suspecting chromosomal issues, they chose to undergo PGT-S at Humgene. The detailed genetic analysis revealed structural abnormalities in their previous embryos. With PGT-S, they successfully selected a healthy embryo, and Funmi is now pregnant with their first child. They describe their experience as “life-changing” and appreciate the personalized care they received at Humgene.
Ngozi and Emeka’s Journey to Overcoming Miscarriages
After three painful miscarriages, Ngozi and Emeka were at a loss. They discovered that Ngozi carried a chromosomal inversion, which was likely causing the miscarriages. Opting for PGT-S at Humgene allowed them to select embryos without the inversion. Ngozi is now in her second trimester with a healthy pregnancy, and the couple is overjoyed to finally be expecting a baby.
Lola and Tunde’s Success with Advanced Maternal Age
At 42, Lola faced challenges with egg quality and chromosomal abnormalities. Seeking a solution, she and her husband Tunde chose Humgene’s PGT-S service. Through careful screening, they were able to identify and select healthy embryos. Lola is now thrilled to be pregnant, and they credit Humgene for helping them achieve their dream of becoming parents.
Frequently Asked Questions about PGT-S
Is PGT-S Safe for the Embryos?
Yes, PGT-S is a safe and well-established procedure. The embryo biopsy process is performed with precision by our skilled embryologists to ensure minimal risk to the embryos. Our advanced techniques at Humgene are designed to protect the integrity and viability of your embryos.
How Long Does the PGT-S Process Take?
The PGT-S process is integrated into your IVF cycle, which typically spans several weeks. The genetic analysis itself usually takes a few days to complete. We’ll provide you with a detailed timeline during your initial consultation, ensuring you know what to expect at each stage.
Can PGT-S Be Combined with Other Genetic Tests?
Yes, PGT-S can be combined with other genetic tests, such as PGT-A (Preimplantation Genetic Testing for Aneuploidy) and PGT-M (Preimplantation Genetic Testing for Monogenic Disorders). This combination offers a comprehensive assessment of the embryos, especially beneficial for couples with multiple genetic concerns.
How Much Does PGT-S Cost?
The cost of PGT-S varies depending on individual circumstances and the specific services required. At Humgene, we provide a detailed cost breakdown during your consultation, ensuring transparency and helping you understand the financial aspects of your treatment.
What Are the Success Rates of PGT-S?
The success rates of PGT-S depend on several factors, including the age of the woman, the quality of the embryos, and the specific chromosomal abnormalities being tested. At Humgene, we have a proven track record of successful PGT-S treatments, and our team will provide you with realistic expectations based on your unique situation.
Take the Next Step with Humgene
Are you ready to explore the benefits of PGT-S and take a proactive step towards a healthy family? Contact Humgene today to schedule your consultation and learn more about our PGT-S services. Our team is here to provide you with the expertise, support, and care you need to make your fertility journey a success.
Phone: +234 810 751 9982
Address: 13 Fadeyi Street, Allen Avenue, Ikeja, Lagos.