PGT-M (Preimplantation Genetic Testing for Monogenic Disorders)
Humgene’s PGT-M Service: Your Pathway to a Healthy Family
Understanding PGT-M: A Lifesaving Solution for Families at Risk
In the complex world of fertility treatments, Preimplantation Genetic Testing for Monogenic Disorders (PGT-M) stands out as a beacon of hope for many couples facing genetic challenges. PGT-M is a revolutionary technology that allows for the screening of embryos for specific genetic disorders caused by single-gene mutations. This advanced form of genetic testing ensures that only embryos free from the targeted genetic condition are selected for implantation, paving the way for a healthier pregnancy and baby.
At Humgene, we are dedicated to helping you navigate your fertility journey with confidence. Our PGT-M services are designed to provide you with peace of mind and the best possible chance for a healthy pregnancy, especially if you have a family history of genetic disorders.
What is PGT-M?
PGT-M, previously known as Preimplantation Genetic Diagnosis (PGD), is a technique used in conjunction with In Vitro Fertilization (IVF) to screen embryos for specific monogenic (single-gene) disorders. This type of genetic testing is crucial for couples who are carriers of hereditary conditions and wish to prevent these disorders from being passed on to their children.
How Does PGT-M Work?
- IVF Process: The PGT-M process begins with the standard IVF procedure, where eggs are retrieved from the ovaries and fertilized with sperm in a laboratory setting to create embryos.
- Embryo Biopsy: Once the embryos reach the blastocyst stage (usually on day 5 or 6), a few cells are carefully removed from each embryo. This process, known as an embryo biopsy, is performed by our skilled embryologists to ensure the integrity and viability of the embryos.
- Genetic Analysis: The biopsied cells are then subjected to comprehensive genetic testing to detect the presence of specific monogenic disorders. This analysis identifies whether the embryos carry the genetic mutations associated with the targeted disorder.
- Embryo Selection: Based on the results of the genetic analysis, only embryos free from the monogenic disorder are selected for transfer. This selection process significantly reduces the risk of passing on genetic diseases and increases the chances of a successful and healthy pregnancy.
Why Choose PGT-M?
PGT-M offers numerous advantages for couples who are at risk of passing on genetic disorders. Here’s why you should consider PGT-M as part of your fertility treatment at Humgene:
- Prevention of Genetic Disorders
The primary benefit of PGT-M is its ability to prevent the transmission of genetic disorders. By screening embryos for specific monogenic conditions, PGT-M ensures that only healthy embryos are selected for transfer. This reduces the risk of your child inheriting a genetic disorder, providing you with peace of mind and a healthier future for your family.
- Increased Success Rates
PGT-M can significantly improve the success rates of IVF by ensuring that only genetically healthy embryos are used for implantation. This increases the likelihood of successful implantation, pregnancy, and live birth, especially for couples with a known genetic risk.
- Targeted and Personalized Treatment
At Humgene, we tailor our PGT-M services to meet your specific needs. Whether you are a carrier of a genetic disorder or have a family history of genetic conditions, our personalized approach ensures that your treatment is aligned with your unique genetic profile and reproductive goals.
- Emotional and Psychological Relief
Knowing that you are taking proactive steps to prevent genetic disorders can provide significant emotional and psychological relief. PGT-M offers reassurance and a sense of control over your reproductive outcomes, reducing the anxiety associated with the risk of passing on genetic diseases.
- Early Detection and Informed Decisions
PGT-M allows for the early detection of genetic disorders at the embryonic stage. This early insight enables you to make informed decisions about your family planning and fertility treatment, helping you choose the best path forward.
- Comprehensive Support
At Humgene, we offer comprehensive support throughout your PGT-M journey. From initial consultation to post-treatment care, our team is here to guide you every step of the way, ensuring that you receive the best possible care and support.
Who Should Consider PGT-M?
PGT-M is an invaluable option for many individuals and couples facing genetic risks. Here are some scenarios where PGT-M can be particularly beneficial:
Carriers of Genetic Disorders
If you or your partner is a carrier of a genetic disorder, PGT-M can help prevent the transmission of the condition to your children. Common monogenic disorders screened by PGT-M include cystic fibrosis, sickle cell anemia, and Huntington’s disease.
Family History of Genetic Conditions
Couples with a family history of genetic conditions often choose PGT-M to ensure that these disorders are not passed on to their offspring. PGT-M provides a safeguard against inheriting genetic diseases present in the family lineage.
Previous Child with a Genetic Disorder
If you have previously had a child with a genetic disorder, PGT-M offers a way to prevent recurrence in future pregnancies. By screening for the specific disorder, PGT-M increases the chances of having a healthy baby in subsequent pregnancies.
Advanced Maternal Age
Women of advanced maternal age are at a higher risk of producing embryos with chromosomal abnormalities. While PGT-M specifically targets monogenic disorders, it can be combined with PGT-A (Preimplantation Genetic Testing for Aneuploidy) to screen for a broader range of genetic issues.
How PGT-M is Performed at Humgene
At Humgene, we take a meticulous and compassionate approach to performing PGT-M, ensuring the highest standards of care and accuracy. Here’s what you can expect from our PGT-M service:
Step 1: Initial Consultation
Your journey with PGT-M begins with an initial consultation with one of our genetic counselors and fertility specialists. During this session, we’ll review your medical history, discuss any known genetic risks, and explain the PGT-M process in detail. This helps us tailor the PGT-M procedure to your specific needs and circumstances.
Step 2: IVF Cycle and Embryo Creation
PGT-M is performed as part of an IVF cycle. We’ll guide you through the process of ovarian stimulation, egg retrieval, and fertilization to create embryos. These embryos will be cultured in our advanced laboratory until they reach the blastocyst stage.
Step 3: Embryo Biopsy
At the blastocyst stage, our experienced embryologists will carefully biopsy a few cells from each embryo. This process is done with precision to ensure the integrity and viability of the embryos. The biopsied cells are then sent to our genetic laboratory for analysis.
Step 4: Genetic Analysis
The biopsied cells undergo comprehensive genetic analysis to detect the presence of the targeted monogenic disorder. Our cutting-edge technology allows us to identify specific genetic mutations with high accuracy, providing detailed information about the genetic status of each embryo.
Step 5: Embryo Selection and Transfer
Based on the results of the genetic analysis, we’ll select the healthiest embryos free from the monogenic disorder for transfer. You’ll receive a detailed report on each embryo’s genetic status, helping you make informed decisions about your treatment. The selected embryos are then transferred into your uterus to achieve pregnancy.
Step 6: Ongoing Support
After the embryo transfer, we provide continued support and monitoring throughout your pregnancy journey. Our team is here to ensure your comfort and answer any questions you may have along the way.
Real-Life Success Stories
Ada and Chinedu’s Journey to a Healthy Family
Ada and Chinedu both carried the sickle cell trait and were concerned about passing on sickle cell anemia to their children. They turned to Humgene’s PGT-M service for help. Through our personalized approach and advanced genetic testing, Ada and Chinedu successfully selected embryos free from the sickle cell mutation. Today, they are proud parents of twin boys who are healthy and thriving. Ada describes their experience as “transformative” and expresses gratitude for Humgene’s expertise and support.
Ifeoma’s Hope After Multiple Miscarriages
Ifeoma had suffered several miscarriages due to a genetic disorder called cystic fibrosis. Feeling hopeless, she and her husband decided to try IVF with PGT-M at Humgene. Through PGT-M, they were able to identify and select embryos that were not affected by cystic fibrosis. Ifeoma is now pregnant with a healthy baby girl and feels deeply grateful for the technology and support that made this possible.
Gbenga and Amaka’s Journey with Huntington’s Disease
Gbenga had a family history of Huntington’s disease, a debilitating genetic disorder. Fearing the risk of passing on the condition, Gbenga and his wife Amaka chose PGT-M at Humgene. The detailed genetic analysis allowed them to select embryos free from the Huntington’s disease mutation. Amaka is now pregnant with a healthy baby boy, and the couple feels relieved and hopeful about their future.
Kemi and Adebayo’s Family Balancing Success
Kemi and Adebayo, already parents to two children with cystic fibrosis, wished to have another child without the genetic disorder. They chose Humgene’s PGT-M service to help them achieve this goal. By accurately identifying and selecting embryos free from the cystic fibrosis mutation, Kemi successfully conceived their third child. Today, they are overjoyed to welcome their healthy baby girl into their family.
Frequently Asked Questions (FAQs) About PGT-M
What Conditions Can PGT-M Screen For?
PGT-M can screen for a wide range of monogenic disorders, including cystic fibrosis, sickle cell anemia, Huntington’s disease, and many others. If you have a specific genetic condition in mind, our genetic counselors can provide detailed information about the testing options available.
Is PGT-M Safe for the Embryos?
Yes, PGT-M is a safe procedure when performed by experienced professionals. The biopsy process is carefully conducted to minimize any risk to the embryos. Our embryologists at Humgene are highly skilled in performing embryo biopsies with precision and care.
How Long Does the PGT-M Process Take?
The PGT-M process is integrated into the standard IVF cycle, which typically takes several weeks. The genetic analysis itself usually takes a few days to complete. Our team will provide you with a detailed timeline during your consultation.
Can PGT-M Be Combined with Other Genetic Tests?
Yes, PGT-M can be combined with other genetic tests, such as PGT-A (Preimplantation Genetic Testing for Aneuploidy), to provide a comprehensive assessment of the embryos. This combination is especially beneficial for couples with multiple genetic concerns or those of advanced maternal age.
How Much Does PGT-M Cost?
The cost of PGT-M varies depending on individual circumstances and the specific services required. At Humgene, we provide a detailed cost breakdown during your initial consultation, ensuring transparency and helping you understand the financial aspects of your treatment.
What Are the Success Rates of PGT-M?
The success rates of PGT-M depend on various factors, including the age of the woman, the quality of the embryos, and the specific genetic condition being tested. At Humgene, we have a proven track record of successful PGT-M treatments, and our team will provide you with realistic expectations based on your unique situation.
Take the Next Step with Humgene
Are you ready to explore the benefits of PGT-M and take a proactive step towards a healthy family? Contact Humgene today to schedule your consultation and learn more about our PGT-M services. Our team is here to provide you with the expertise, support, and care you need to make your fertility journey a success.
Phone: +234 810 751 9982
Address: 13 Fadeyi Street, Allen Avenue, Ikeja, Lagos.